Together with the program committee and the Principal Investigators of DCVA consortia, we have put together a varied program for the 5th DCVA Translational Cardiovascular Research Meeting ‘Together we beat as one’.
Download the program here.
Thursday, June 24
09.30 – 18.30 hrs CEST
| 09.30 | Plenary opening Prof. dr. Pieter Doevendans (member of the board of the Netherlands Heart Institute) Dutch CardioVascular Alliance Prof. dr. D.J. Duncker (DCVA) Lecture ‘Biomarkers in cardiovascular disease: what is the next step?’ Prof. dr. Naveed Sattar (University of Glasgow) |
| 10.30 | Short Break |
| 10.45 | Fellowship 2021: Candidates will present their application to work for up to one year in an international top quality academic centre anywhere in the world to gather skills or knowledge that can be applied in a Dutch academic centre. 1. Pranav Bhagirath (Amsterdam) 2. Jiayi Pei (Utrecht) 3. Irene van Blokland (Groningen) 4. Rachel van der Velden (Maastricht) |
| 11.45 | Public Private Partnerships in Health & Care Carmen van Vilsteren, Health~Holland |
| 11.45 | Non-dilutive funding for (clinical) research and innovations Nawal Bahia El Idrissi, Catalyze |
| 12.00 | Lunch Break and online Posters: during the lunch you are invited to take a look at the posters which are presented on our website. |
| 13.00 | Workshop organized by Young@Heart: Personal media strategy – a quick guide into the world of social and traditional media More information can be found here. |
| 13.00 | Session “Heart failure with preserved ejection fraction (HFpEF)” Chairs: Rudolf de Boer (Groningen) & Stephane Heymans (Maastricht) 1. New algorithms for HFpEF diagnostics Vanessa van Empel (Maastricht) 2. The new HFpEF scores: what’s the pathophysiology behind it? Carsten Tschöpe (Berlin, Germany) 3. HFpEF: current phase I and II trials Louis Handoko (Amsterdam) 4. Large animal models of HFpEF Daphne Merkus (Rotterdam and Munich, Germany) 5. Deltaplan Hartfalen Steven Chamuleau (Amsterdam) |
| 13.00 | Session “New models: in-vivo, in-vitro, in-silico, on-the-chip: Vesicles“ Chairs: Leon Schurgers (Maastricht) & Andries van der Meer (Twente) 1. Small animal model for stroke Rick Dijkhuizen (Utrecht) 2. Large animal model for stroke Heleen van Beusekom (Rotterdam) 3. Plaque-on-a-chip: a model to understand plaque ruptur Kim van der Heiden (Rotterdam) 4. Novel in vitro organ on a chip and 2D assays to test impact human plasma-derived circulating factors on EC function Vincent van Duinen (Leiden) 5. Diabetic nephropathy alters the distribution of circulating angiogenic microRNAs among extracellular vesicles, HDL, and Ago-2 Roel Bijkerk (Leiden) 6. Studying the right heart myocardium in pulmonary hypertension using 3D engineered heart tissue Aida Llucià Valldeperas (Amsterdam and Leiden) |
| 13.00 | Session “DNA biomarkers for disease risk prediction“ Chairs: Jessica van Setten (Utrecht) & Arthur Wilde (Amsterdam) 1. Polygenic risk scores in complex cardiovascular disorders Steve Lubitz (Boston, US) 2. Opposing common variant contributions to HCM and DCM Rafik Tadros (Montreal, Canada) 3. Different genetic architectures of inherited cardiac arrhythmias Connie Bezzina (Amsterdam) 4. SCN5A founder mutations in Limburg Monika Stoll (Maastricht) 5. Rare variants as a cause of atrial fibrillation Peter van Tintelen (Utrecht) 6. Detection of two new DNA/chromatin regions increasing DCM risk Sophie Garnier (Paris, France) |
| 13.00 | Session COVID-19 Chairs: Roland van Kimmenade (Nijmegen) & Marie-José Goumans (Leiden) 1. Contribution of inflammatory mechanisms of cardiovascular disease to COVID-19 comorbidity Tomasz Guzik (Glasgow, UK) 2. COVID- The endothelium on the rack Jurjan Aman (Amsterdam) 3. The role of cardiovascular disease in the COVID-19 pandemic – most important insights obtained from the CAPACITY-COVID registry Marijke Linschoten (Utrecht) 4. COVID-19 associated mechanisms of hypercoagulability Magdi Nagy (Maastricht) 5. SARS-CoV-2 and myocardial involvement in the elite athlete’s heart: Olympic showstopper or food for thought? Harald Jørstad (Amsterdam) 6. Modeling and attacking sars-cov2-induced cardiovascular disease with organs on chip Robert Passier (Twente) |
| 13.00 | Session “Early recognition and early intervention: AF and comorbidities“ Chairs: Michiel Rienstra (Groningen) & Natasja de Groot (Rotterdam) 1. Ex vivo heart perfusion: a platform for patient-tailored therapy of heart failure and atrial fibrillation Yannick Taverne (Rotterdam) 2. Atrial fibrillation: The electrical fingerprint Mathijs van Schie (Rotterdam) 3. Atrial fibrillation: The molecular fingerprint Kennedy Ramos (Amsterdam) 4. The role of circulating non-coding RNAs in vascular homeostasis and disease Anton Jan van Zonneveld (Leiden) 5. When is the optimal moment to cardiovert AF? Nikki Pluymakers (Maastricht) 6. Population models of AF, a new tool to study effects of comorbidities and responsiveness to therapy Jordi Heijman (Maastricht) |
| 14.30 | Short Break |
| 15.00 | Einthoven Prizes 3 Candidates will present their thesis: 1. Potential detrimental effects of exercise on the heart Vincent Aengevaeren (Nijmegen) 2. Diagnostic evaluation of chest pain: The role of non-invasive cardiac imaging Martijn Smulders (Maastricht) 3. Dissecting genetic risk in common and rare inherited disorders Najim Lahrouchi (Amsterdam) |
| 15.45 | Workshop organized by Young@Heart: Networking – how to find, approach, and connect with project partners, mentors, and future employers More information can be found here. |
| 15.45 | Session “Early recognition and early intervention: Modern strategies“ Chairs: Joline Beulens (Amsterdam) & Jaap Kappelle (Utrecht) 1. Prehospital stroke triage with devices or decision tools: Bob Roozenbeek (Rotterdam) 2. Speeding up time to endovasculair stroke intervention: Results MR CLEAN NoIV trial. Bart Emmer (Amsterdam) 3. The importance of physical examination: Frans Rutten (Utrecht) 4. Cardiac biomarkers in primary care: Rudolf de Boer (Groningen) 5. Early diagnosis of cardiovascular diseases in primary care: Amy Groenewegen (Utrecht) and Victor Zwartkruis (Groningen) |
| 15.45 | Session “Diagnostic tools and valorization” Chairs: Michiel Rienstra (Groningen) & Jordi Heijman (Maastricht) 1. Tricks and tips in valorisation of AI solutions Henk Marquering (Amsterdam) 2. Deep learning for image biomarker extraction / prediction of outcome Theo van Walsum (Rotterdam) 3. Heart sounds: new wine in new bags for continuous disease monitoring Frits Prinzen (Maastricht) 4. ECG for characterization of the AF substrate Stef Zeemering (Maastricht) 5. Social distancing in AF management: TeleCheck AF Dominik Linz (Maastricht) 6. Towards classification of AF with implatable devices: data from RACE V Bao-Oanh Nguyen (Groningen) |
| 15.45 | Session “New Models: in-vivo, in-vitro, in-silico, on-the-chip: Heart“ Chairs: Miranda Nabben (Maastricht) & Daan Westenbrink (Groningen) 1. Models to study allelic imbalance in cardiomyopathies on a single cell level Judith Montag (Hannover, Germany) 2. Modeling genetic heart disease in mouse models Nienke Stege (Groningen) 3. High-throughput studies in iPSC-derived cardiomyocytes Rafeeh Soleimanidinani (Amsterdam) 4. Zebrafish to model pediatric cardiomyopathy Judith Verhagen (Rotterdam) 5. Naturally occurring canine and feline cardiomyopathy models Frank van Steenbeek (Utrecht) 6. Engineered heart tissue modeling Edgar Nollet (Amsterdam) |
15.45 | Session “Sex-differences in cardiovascular disease“ Chairs: Vanessa van Empel (Maastricht) & Emma Louise Robinson (University of Colorado USA) 1. Sex differences in atherosclerosis: what’s behind? Hester den Ruijter (Utrecht) 2. Age- and sex-specific differences in atherosclerotic plaque composition Marie de Bakker (Rotterdam) 3. Sex-differences in atrial fibrillation mechanisms Ulrich Schotten (Maastricht) 4. Migraine in Women: from Headache to Heartache Antoinette Maassen van den Brink (Rotterdam) 5. Sex differences in right heart adaptation to pulmonary hypertension Frances de Man (Amsterdam) 6. Sex differences in lipid metabolism Jeanine Roeters van Lennep (Rotterdam) |
| 15.45 | Session “Omics in atherosclerosis” Chairs: Johan Kuiper (Leiden) & Sander van der Laan (Utrecht) 1. The paradox of IL1b, perivascular cell inflammation, and atherosclerosis Gary Owens (Virginia, US) 2. Single-cell analysis of T cells in the human atherosclerotic lesions Marie Depuydt (Leiden) 3. Transcriptomic based clustering of advanced atherosclerotic plaques: revisiting the lesion determinants that identify the vulnerable patient Michal Mokry (Utrecht) 4. Single-cell work on macrophages in human atherosclerosis Koen Prange (Amsterdam) 5. GWAS to single cell: Atherosclerotic disease susceptibility loci through the lens of single cells of advanced human atherosclerotic plaques Lotte Slenders (Utrecht) 6. Macrophage repressive histone modifications in atherosclerosis Annette Neele (Amsterdam) |
| 17.15 | Short Break |
| 17.30 | Lecture of Dr. Sean Wu (Stanford Cardiovascular Institute and Stanford University School of Medicine): “Dissecting the Complex Interplay Between Proliferation and Contractile Force Generation in Single Cardiomyocytes.” |
| 18.15 | Awarding Fellowships and Einthoven Prizes Plenary Closing by Prof. dr. Wouter Jukema (member of the board of the Netherlands Heart Institute) |
| 18.30 | Young@Heart social event If you want to participate, you can indicate this when you register. More information will follow after registration. |